To consider the following: 1) Development Permit for construction of a new approximately 70-foot tall four-story building with a subterranean basement totaling approximately 377,256 square feet, with a loading dock, rooftop equipment, landscaping, and supporting infrastructure and circulation improvements; 2) Introduction of an ordinance amending the Amgen Center Specific Plan (SP-16) to increase the maximum allowable building height standard in Height District 2 from 55 feet to 75 feet, consistent with the Industrial Flex height standard established by the 2045 General Plan, modify height standards for modern rooftop equipment, modification of the boundaries of the Height District Map within the Specific Plan area, clarification of gross floor area definition, modify internal parking requirements, and modify architectural standards relating to setbacks and massing; and 3) Protected Tree Permit for the removal of four Coast Live Oak trees. The project is in the Industrial Park (M-1) zone in the Amgen Center Specific Plan 16 (SP-16) area.